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NEWS: Vitamin C Infusion in Sepsis and Severe Acute Respiratory Failure (the CITRIS-ALI Trial)

By Fowler AA, Truwit JD, Hite RD, et al. Effect of vitamin C infusion on organ failure and biomarkers of inflammation and vascular injury in patients with sepsis and severe acute respiratory failure. JAMA 2019; 322(13):1261-1270. Reviewed by: Kyle Hobbs, MD Read the article .* ...


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NEWS: Optimizing MAP After Cardiac Arrest Increases Brain Tissue Oxygenation

By Sekhon MS, Gooderham P, Menon DK, et al. The burden of brain hypoxia and optimal mean arterial pressure in patients with hypoxic ischemic brain injury after cardiac arrest. Crit Care Med 2019; 47(7):960-969. Reviewed by: Kyle Hobbs, MD Read the article .* *You will need to...


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NEWS: Tranexamic Acid Administration Following Head Trauma in a Combat Setting: Does Tranexamic Acid Result in Improved Neurologic Outcomes?

By Morte D, Lammers D, Bingham J, Kuckelman J, Eckert M, Martin M. Tranexamic acid administration following head trauma in a combat setting: Does tranexamic acid result in improved neurologic outcomes? J Trauma Acute Care Surg. 2019 Jul;87(1):125-129 Reviewed by Wazim Mohamed, MD Read...


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NEWS REVIEW: The Role of EEG in Comatose Patients

By Kyle Hobbs, MD and Sara Stern-Nezer, MD Coma secondary to acute brain injury is extremely common in the neurocritical care unit, but prognosis after coma is challenging. Electroencephalography provides a window into the comatose brain, revealing brain activity even in the absence of...


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Thrombolysis Guided by Perfusion Imaging up to 9 Hours after Onset of Stroke

By Ma, H., Campbell, B.C., Parsons, M.W., et al. New England Journal of Medicine , 380 (19), pp.1795-1803. Summary Methods: The recently successful thrombectomy trials (DEFUSE 3 and DAWN) have set a paradigm of reperfusion based on tissue viability assessed by perfusion imaging...


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Can We Better Predict Thromboembolism in Coagulopathic Patients Using Thromboelastography?

By Harahsheh, Y., Duff, O.C., Ho, K.M. “Thromboelastography predicts thromboembolism in critically ill coagulopathic patients.” CCM. 2019;47(6): 826-832. Summary : Thromboembolism is the main cause of preventable hospital-associated death. Coagulopathy is common in the ICU, often resulting in...


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NEWS: Association Between Elevated Mean Arterial Blood Pressure and Neurologic Outcome After Resuscitation From Cardiac Arrest

Authors: Roberts BW, Kilgannon JH, Hunter BR, et al. Association Between Elevated Mean Arterial Blood Pressure and Neurologic Outcome After Resuscitation From Cardiac Arrest: Results From a Multicenter Prospective Cohort Study. CCM. 2019 Jan;47(1):93-100. Reviewed by: Sara Stern-Nezer, MD, MPH...


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NEWS: Postarrest Steroid Use in Cardiac Arrest Survivors

Authors: Tsai MS, Chuang PY, et al. Postarrest steroid use may improve outcomes of cardiac arrest survivors. CCM. 2019 Feb;47(2):167-175. Reviewed by: Sara Stern-Nezer, MD, MPH; and Kyle Hobbs, MD Read the article. * *You will need to log in to US National Library of Medicine National...


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NEWS: DEFUSE 3 Non-DAWN Patients: A Closer Look at Late Window Thrombectomy Selection

Authors: Leslie-Mazwi TM, Hamilton S, et al. DEFUSE 3 Non-DAWN Patients: A Closer Look at Late Window Thrombectomy Selection. Stroke . 2019 Feb 6 :STROKEAHA-118 . Reviewed by: Wazim Mohamed, MD, Assistant Professor of Neurology, Division of Neurotrauma and Critical Care Neurology, Wayne State...


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NEWS: Development and Validation of a Prognostic Model of Swallowing Recovery and Enteral Tube Feeding After Ischemic Stroke

Authors: Galovic M, Stauber AJ, Leisi N, et al. Development and Validation of a Prognostic Model of Swallowing Recovery and Enteral Tube Feeding After Ischemic Stroke. JAMA Neurol . Published online February 11, 2019. doi :10.1001/jamaneurol.2018.4858 Reviewed by: Lara L. Zimmermann, MD, Co...