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NEWS: No Mortality Benefit with a Strategy of Nonsedation in Mechanically Ventilated Patients

Olsen HT et al. Nonsedation or light sedation in critically ill, mechanically ventilated patients. NEJM. DOI: 10.1056/NEJMoa1906759 Reviewed by Sanjeev Sivakumar, MD Read the article .* Background/Methods Sedating patients who require mechanical ventilation has been...


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Interim Guidance for Basic and Advanced Life Support in Adults, Children, and Neonates With Suspected or Confirmed COVID-19

Circulation (04/09/20) doi: 10.1161/CIRCULATIONAHA.120.047463 Edelson, Dana P.; Sasson, Comilla; Chan, Paul S.; et al. https://www.ahajournals.org/doi/pdf/10.1161/CIRCULATIONAHA.120.047463 The American Heart Association (AHA) and seven other medical organizations have issued interim...


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Haptoglobin Is Associated with Increased Early Perihematoma Edema Progression in Spontaneous Intracranial Hemorrhage

International Journal of Stroke (04/07/20) doi: 10.1177/1747493020912602 Halstead, Michael R.; Mould, W. Andrew; Sheth, Kevin N.; et al. https://journals.sagepub.com/doi/abs/10.1177/1747493020912602 New research highlights the role of haptoglobin (Hp) phenotype in understanding the...


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NEWS: Improved Neurologic Outcome Seen With Targeted Temperature Management to 33 Degrees Versus 36 Degrees

Johnson NJ, Danielson KR, Counts CR, et al. Targeted temperature management at 33 versus 36 degrees: A retrospective cohort study. Crit Care Med . 2020 Mar;48(3):362-369. Reviewed by Wazim Mohamed, MD Read the article .* *You will need to log in to US National Library of...


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NEWS: Does Tailored Duration of TTM Influence Outcome After Cardiac Arrest?

Sawyer KN, Humbert A, Leroux BG, et al. Relationship between duration of targeted temperature management, ischemic interval, and good functional outcome from out-of-hospital cardiac arrest. Crit Care Med 2020; 48(3):370-377. Reviewed by Alexis Steinberg, MD Read the article .* ...


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Ventilation Time and Prognosis After Stroke Thrombectomy: The Shorter, the Better!

European Journal of Neurology (02/17/20) doi: 10.1111/ene.14178 Fandler‐Höfler, Simon; Heschl, Stefan; Kneihsl, Markus; et al. For stroke patients receiving mechanical thrombectomy (MT), extubation should occur as early as safely possible, Austrian researchers report, citing as association...


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Effect of Intravenous Tenecteplase Dose on Cerebral Reperfusion Before Thrombectomy in Patients With Large Vessel Occlusion Ischemic Stroke

Journal of the American Medical Association (02/20/20) doi: 10.1001/jama.2020.1511 Campbell, Bruce C. V.; Mitchell, Peter J.; Churilov, Leonid; et al. While I.V. thrombolysis with tenecteplase is superior to alteplase in improving cerebral reperfusion in ischemic stroke patients, it was...


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NEWS: Intensive Lipid Lowering After Ischemic Stroke Are Better than Moderate Lowering

Amarenco P, Kim JS, Labreuche H, et al. A comparison of two LDL cholesterol targets after ischemic stroke. NEJM 2020; 382:9-19. Reviewed by Kyle Hobbs, MD Read the article . Summary : Intensive lipid lowering therapy is recommended after ischemic stroke or TIA, but the exact...


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NEWS: Does DDAVP Prevent Hematoma Expansion in Patients with Mild TBI on Antiplatelet Agents?

Barletta JF, Abdul-Rahman D, Hall ST, Mangram AJ, Dzandu JK, Frontera JA, Zach V. The role of desmopressin on hematoma expansion in patients with mild traumatic brain injury prescribed pre-injury antiplatelet medications. Neurocritical Care. 2020 Jan 2. doi: 10.1007/s12028-019-00899-x ...


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Intravenous Immunomodulatory Nanoparticle Treatment for Traumatic Brain Injury

Annals of Neurology (01/10/20) doi.org/10.1002/ana.25675 Sharma, Sripadh; Ifergan, Igal; Kurz, Jonathan E.; et al. Immunomodulatory nanoparticles (IMPs) – which ablate a particular subset of hematogenous monocytes – are a strong therapeutic candidate for traumatic brain injury (TBI), new...