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Literature Review

By Kyle Hobbs, MD, and Sara Stern-Nezer, MD Due to their efficacy and favorable rates of complications when compared to vitamin K antagonist therapy, direct or novel oral anticoagulant (NOAC/DOAC) use is now widespread, and reversal agents exist for many of these medications. The studies...


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NEWS: Does Early Prophylactic Hypothermia Improve Outcomes After Severe TBI? Results of the Prophylactic Hypothermia to Lessen Traumatic Brain Injury-Randomized Clinical Trial (POLAR-RCT)

Authors: Cooper DJ, Nichol AD, Bailey M, Bernard S, Cameron, PA, Fili-Floury S, Forbes A, Gantner D, Higgins AM, Huet O, Kasza J, Muray L, Newby L, Presneill JJ, Rashford S, Rosenfeld JV, Stephenson M, Vallance S, Varma D, Webb SAR, Trapani T, McArthur C. “Effect of early sustained prophylactic...


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NEWS: Lacosamide Compared to Fosphenytoin: Is There a Difference in Response to Treatment in Patients With Nonconvulsive Seizures?

Authors: Husain, AM, Lee, JW, Kolls, BJ, et al. “Randomized trial of lacosamide versus fosphenytoin for nonconvulsive seizures.” Ann Neurol 2018; 83:1174-1185 Reviewed by: Sara Stern-Nezer, MD, MPH, Assistant Clinical Professor, University of California, Irvine Read the article .* * You...


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NEWS: Does Vitamin D Status Affect Outcomes in the Neurocritical Care Population?

Authors: Guan, J., Karsy, M., Brock, A. et al. “Vitamin D status and 3-month Glasgow Outcome Scale scores in patients in neurocritical care: prospective analysis of 497 patients.” J Neurosurg 128: 1635-1641 Reviewed by: Sara Stern-Nezer, MD, MPH, Assistant Clinical Professor, University of...


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NEWS: Variations in ICP After Decompressive Craniectomy Are Associated With Outcomes

Authors: Sauvigny T, Göttsche J, Czorligh P, Vettorazzi E, Westphal M, and Regelsberger J. Intracranial pressure (ICP) in patients undergoing decompressive craniectomy: new perspective on thresholds. J Neurosurgery . March 2018; 128(3): 819-827 Reviewed by: Sara Stern-Nezer, MD, MPH,...


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NEWS: No Benefit to IV Sodium Bicarbonate or Acetylcysteine for Prevention of Contrast-Associated Acute Kidney Injury in High-Risk Patients: The PRESERVE Trial

Read the article . Listen to the podcast . Author: Weisbord, SD, Gallagher M, Jneid H, et al. “Outcomes after angiography with sodium bicarbonate and acetylcysteine.” NEJM 2018; 378(7): 603-614 Reviewed by: Sara Stern-Nezer, MD, MPH, Assistant Clinical Professor, University of California,...