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Haptoglobin Is Associated with Increased Early Perihematoma Edema Progression in Spontaneous Intracranial Hemorrhage

By Currents Editor posted 05-07-2020 09:33


International Journal of Stroke (04/07/20) doi: 10.1177/1747493020912602

Halstead, Michael R.; Mould, W. Andrew; Sheth, Kevin N.; et al.

New research highlights the role of haptoglobin (Hp) phenotype in understanding the progression of perihematomal volume in spontaneous intracerebral hemorrhage. The study sought to determine whether rates of early perihematomal edema formation in people with Hp 1-1 phenotype differ from those with Hp 2-1 and Hp 2-2. Among 166 participants, taken from three prospectively collected intracranial hemorrhage cohorts, there were 15 patients with Hp 1-1, 86 with Hp 2-1, and 65 with Hp 2-2. Multivariate analysis revealed a significantly higher estimated mean rate of early change in perihematomal volume at 1.15 for Hp 1-1 compared with the other Hp phenotypes. There was no difference between Hp phenotypes for mortality or discharge Modified Rankin Score. Further research is needed, but the increased mean rate of early change in perihematomal volume for Hp 1-1 phenotype indicates that “haptoglobin phenotype may be a key player in understanding the multiphasic progression of perihematomal volume in spontaneous intracerebral hemorrhage,” the authors conclude.


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DOI: 10.1056/NEJMoa1916870
 Reviewed by Sanjeev Sivakumar,MD Read the article .*   *You will need to log in ...