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Intravenous Immunomodulatory Nanoparticle Treatment for Traumatic Brain Injury

By Currents Editor posted 02-03-2020 12:22

  

Annals of Neurology (01/10/20)  doi.org/10.1002/ana.25675
Sharma, Sripadh; Ifergan, Igal; Kurz, Jonathan E.; et al.

Immunomodulatory nanoparticles (IMPs) – which ablate a particular subset of hematogenous monocytes – are a strong therapeutic candidate for traumatic brain injury (TBI), new research shows. Researchers from the Northwestern University Feinberg School of Medicine in Chicago administered an intravenous infusion of IMPs containing 500 nm carboxylated‐poly(lactic‐co‐glycolic) acid into wild‐type C57BL/6 mice following controlled cortical impact and closed head injury. In both models of experimental TBI, the infusion resulted in preservation of tissue and neurological function. Additionally, following acute treatment, fewer immune cells infiltrated into the brain, the inflammatory status of the infiltrating cells was mitigated, and there was greater electrophysiologic visual function, improved long-term motor behavior, fewer edemas, and lower lesion volumes. The results indicate that IMPs “are a clinically translatable acute intervention for TBI with a well‐defined mechanism of action and beneficial anatomic and physiologic preservation and recovery,” according to the researchers.

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