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Endovascular Therapy for Acute Stroke with a Large Ischemic Region

By Currents Editor posted 03-14-2022 11:56


Endovascular Therapy for Acute Stroke with a Large Ischemic Region
New England Journal of Medicine (02/09/22) DOI: 10.1056/NEJMoa2118191
Yoshimura, Shinichi; Sakai, Nobuyuki; Yamagami, Hiroshi;

Researchers in Japan explored the effect of endovascular therapy for acute ischemic stroke with large infarctions. In a sample population of 203 participants, they randomized one-half to receive usual medical care only and the other one-half to receive usual medical care plus endovascular therapy. Investigators calculated the share of modified Rankin scale disability scores between 0 and 3 in each group at 90-day follow-up and the proportion of patients in each group registering improvements of 8 points on more on the National Institutes of Health Stroke Scale score at 48 hours. Based on that data, the study authors concluded that patients suffering large cerebral infarctions experienced better functional outcomes with endovascular therapy than with medical care alone. However, patients who received endovascular therapy were much more likely to experience intracranial hemorrhage than were those who received standard care.


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