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Direct Oral Anticoagulants Versus Warfarin in the Treatment of Cerebral Venous Thrombosis (ACTION-CVT): A Multicenter International Study

By Currents Editor posted 03-23-2022 11:57

  

Direct Oral Anticoagulants Versus Warfarin in the Treatment of Cerebral Venous Thrombosis (ACTION-CVT): A Multicenter International Study
Stroke (02/10/22) DOI: 10.1161/STROKEAHA.121.037541
Yaghi, Shadi; Shu, Liqi; Bakradze, Ekaterina; et al.

https://www.ahajournals.org/doi/10.1161/STROKEAHA.121.037541 

An international retrospective study compared direct oral anticoagulants (DOACs) with warfarin in a real-world cerebral venous thrombosis (CVT) cohort. The study included 845 patients with CVT who received oral anticoagulants from January 2015 through December 2020. Among the patients, 33.0% received DOACs, 51.8% received warfarin, and 15.1% received both treatments at different times. In all, there were 5.68 recurrent thromboses, 3.77 major hemorrhages, 1.84 deaths per 100 patient-years over a median follow-up of 345 days. For the 525 patients who met the recanalization analysis inclusion criteria, 36.6% had complete recanalization, 48.2% had partial, and 15.2% had no recanalization. Overall, treatment with DOACs had a similar risk of recurrent venous thrombosis, death, and rate of partial/complete recanalization compared with warfarin; however, there was a lower risk of major hemorrhage with DOACs. Large prospective or randomized studies are needed to confirm these findings, the authors conclude.

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