Blog Viewer

Prevalence, Characteristics, and Outcomes of Undetermined Intracerebral Hemorrhage: A Systematic Review and Meta-Analysis

By Currents Editor posted 09-02-2021 11:18

  

Prevalence, Characteristics, and Outcomes of Undetermined Intracerebral Hemorrhage: A Systematic Review and Meta-Analysis

Stroke (08/04/21) DOI: 10.1161/STROKEAHA.120.031471

Malhotra, Konark; Zompola, Christina; Theodorou, Aikaterini; et al.

https://www.ahajournals.org/doi/10.1161/STROKEAHA.120.031471 

Researchers evaluated the prevalence, radiological characteristics, and clinical outcomes of intracerebral hemorrhage (ICH) of undetermined etiology. The study involved a systematic review and meta-analysis of studies involving patients with spontaneous ICH, as well as an assessment of the rates for ICH secondary to hypertensive arteriopathy and cerebral amyloid angiopathy. Using data from 24 studies including 15,828 spontaneous ICH patients with a mean age of 64.8 years, the researchers calculated the pooled prevalences of hypertensive arteriopathy undetermined ICH, and cerebral amyloid angiopathy at 50%, 18%, and 12%, respectively. The volume of cerebral amyloid angiopathy ICH was 24.7 mL, compared with 16.2 mL for hypertensive arteriopathy ICH and 15.4 mL for undetermined ICH. The rates of short-term mortality and concomitant intraventricular hemorrhage for patients with undetermined ICH were 33% and 38%, respectively. A subgroup analysis showed a higher rate of undetermined ICH in studies that did not employ an etiology-based classification; however, there was no difference seen between studies based on the completion of detailed neuroimaging to measure the rates of undetermined ICH. Based on their findings, the authors conclude, "The etiology of spontaneous ICH remains unknown or cryptogenic among 1 in 7 patients in studies using etiology-oriented classification and among 1 in 4 patients in studies that avoid using etiology-oriented classification."

#LiteratureWatch

FURTHER READING
“Stories of Hope” is a popular column on the Neurocritical Care Society’s Currents content center. This series has been uplifting patients and providers alike since its founding. To support NCS’s Curing Coma ® initiative, which aims to develop and implement coma treatment strategies that improve ...
Verticalization for Refractory Intracranial Hypertension: A Case Series Neurocritical Care (08/17/21) DOI: 10.1007/s12028-021-01323-z Lachance, Brittany Bolduc; Chang, WanTsu; Motta, Melissa; et al. https://link.springer.com/article/10.1007%2Fs12028-021-01323-z   Researchers present ...
Hana Nobleza, Marin Darsie, H.E. Hinson, Deepa Malaiyandi, and Diana Greene-Chandos The past year has been hard for all of us. Our resilience, commitment and passion to our patients, and profession have been put to the test. Despite the challenge that the year brought, the Inclusion in Neurocritical ...