Blog Viewer

Global Incidence of Neurological Manifestations Among Patients Hospitalized With COVID-19—A Report for the GCS-NeuroCOVID Consortium and the ENERGY Consortium

By Currents Editor posted 06-01-2021 08:40

  

JAMA Network Open (05/11/21) DOI: 10.1001/jamanetworkopen.2021.12131

Chou, Sherry H.-Y.; Beghi, Ettore; Helbok, Raimund; et al.

https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2779759

Neurological manifestations are common among patients hospitalized with COVID-19, according to new research, and are associated with an increased risk for in-hospital mortality. The cohort study — which involved 3,744 patients hospitalized with COVID-19 in 13 countries on four continents — sought to determine the neurological incidence of neurological manifestations of COVID-19 and investigate their relationship with in-hospital mortality. Patients were divided into three cohorts. Overall, 82% of the patients had self-reported or clinically captured neurological symptoms. The most frequently self-reported symptoms were headache (37%) and amnosia or ageusia (26%), while the most prevalent neurological signs or syndromes were acute encephalopathy (49%) coma (17%), and stroke (6%). The incidence of meningitis or encephalitis were rare, affecting less than 1% of hospitalized COVID-19 patients. After adjusting for study site, age, sex, race, and ethnicity, the presence of clinically captured neurologic signs or syndromes was associated with a higher risk of mortality while hospitalized (adjusted odds ratio, 5.99). In addition, the risk for developing neurological signs or syndromes was linked with having preexisting neurological disorders (adjusted odds ratio, 2.23). "Using a global network with standardized protocols and common data elements is critical to facilitate further studies to understand COVID-19 neurological manifestations, including disease progression, associations with long-term outcomes, pathobiological mechanisms, and societal impact," the authors conclude.

#LiteratureWatch

FURTHER READING
Donald Langan, MD, PharmD, Alexandra Schroeder, PA-C Ischemic strokes in younger adults, those 18 to 50 years old, account for approximately 10% to 15% of all ischemic strokes. Risk factors for stroke between younger and older patients tend to be similar. Younger patients suffer from cardioembolic ...
During the 2nd annual World Coma Day , NCS and the Curing Coma ® Campaign invited patients and their providers to share their stories of recovery, in video format. Below you will hear the story of little Eli. Elijiah (Eli) and his parents Victor and Jannette, as they discuss an April 2021 car crash ...
Clinical Neurophysiology (05/06/22) DOI: 10.1016/j.clinph.2022.04.018 Amorim, Edilberto; Firme, Marcos S.; Zheng, Wei-Long; et al. https://www.sciencedirect.com/science/article/abs/pii/S1388245722002619 A recent study sought to estimate the prevalence of seizures and ictal-interictal continuum ...