Blog Viewer

Intravenous Immunomodulatory Nanoparticle Treatment for Traumatic Brain Injury

By Currents Editor posted 02-03-2020 12:22


Annals of Neurology (01/10/20)
Sharma, Sripadh; Ifergan, Igal; Kurz, Jonathan E.; et al.

Immunomodulatory nanoparticles (IMPs) – which ablate a particular subset of hematogenous monocytes – are a strong therapeutic candidate for traumatic brain injury (TBI), new research shows. Researchers from the Northwestern University Feinberg School of Medicine in Chicago administered an intravenous infusion of IMPs containing 500 nm carboxylated‐poly(lactic‐co‐glycolic) acid into wild‐type C57BL/6 mice following controlled cortical impact and closed head injury. In both models of experimental TBI, the infusion resulted in preservation of tissue and neurological function. Additionally, following acute treatment, fewer immune cells infiltrated into the brain, the inflammatory status of the infiltrating cells was mitigated, and there was greater electrophysiologic visual function, improved long-term motor behavior, fewer edemas, and lower lesion volumes. The results indicate that IMPs “are a clinically translatable acute intervention for TBI with a well‐defined mechanism of action and beneficial anatomic and physiologic preservation and recovery,” according to the researchers.


By Wade Smith, MD, PhD, FNCS, President, NCS Board of Directors, Professor of Neurology, UCSF; and Sharon C. Allen, NCS Executive Director As we end 2020, we open a new year with much anticipation for better world health. Many of you have qualified as Level 1A priority for COVID-19 vaccination and ...
By Matilda Dervisevic 1 , Chetan Sateesh Nayak 2  and Francisco Gomez 3 1 Univeristy of Missouri Medical School 2 Department of Neurology, University of Missouri 3 Department of Neurology, University of Missouri Refractory status epilepticus (RSE) is a condition in which there is continuing ...
By Eric Lawson, Masoom Desai and Aarti Sarwal Over the last decade, social media has revolutionized the connectivity of our medical community by providing a global, easily accessible and dynamic platform to share information. It has transformed into a vital, multi-purpose and widely accepted healthcare ...