Blog Viewer

Poisoning with Ethanol and 2-Propanol-Based Hand Rubs: Give Caesar What Belongs to Caesar!

By Currents Editor posted 02-11-2019 14:27

  

By Bruno Mégarbane, Antoine Villa

To the Editor,

We read with great interest the practical pearl report by Henry-Lagarrigue and colleagues [1] and would like to comment on their interpretation of their poisoned patient’s features. The authors reported a massive ingestion of alcohol hand rub (composition: 43% ethanol and 16% 2-propanol) in a 33-year-old depressed woman resulting in a profound coma with a transient mild lactate elevation (initial blood concentration: 3.4 mmol/l and peak blood concentration: 4.8 mmol/l). Outcome was favorable following airway support with mechanical ventilation for 6 h. The authors attributed the deep coma to ethanol and the observed transient hyperlactatemia to the liver alcohol dehydrogenase (ADH)-mediated metabolism of 2-propanol, reported to be a two-step pathway: transformation of 2-propanol to propylene glycol and oxidation of propylene glycol to lactic and pyruvic acids.

Read more

#NCJ

​​
FURTHER READING
By Roy Poblete, MD, David Seder, MD, Gene Sung, MD     Since the first Emergency Neurologic Life Support (ENLS) course, there has always been a great deal of interest in developing an advanced learning follow-up course. The Neurocritical Care Society is now proud to present the brand-new ...
The Currents Editorial Board is seeking Stories of Hope submissions for 2020. Stories of Hope tells the stories of patients who have fought their way to recovery and the experiences of their family and/or medical providers. By sharing these stories, we remind each other of what we are all working ...
By Pouya Alexander Ameli, MD, MS Neurocritical Care Fellow, Emory University Chair-Elect, Trainee Section   Naomi Niznick, MD PGY3 Neurology Resident, The Ottawa Hospital Trainee Section Leadership Committee     In Homer’s The Odyssey , Odysseus asks for his friend “Mentor” to watch ...