Neurocritical Care Society

Literature Watch

Direct Oral Anticoagulant Use Within 48 Hours Is Not Associated With Increased Intracerebral Hemorrhage After Thrombolysis for Acute Ischemic Stroke

Written By: Matthew Bower, MD; Sara Stern-Nezer, MD, MPH

Direct oral anticoagulants (DOACs) have become the standard treatment for stroke prevention in nonvalvular atrial fibrillation (AF), and use of...

Literature Watch

Literature Review

Written By: Kyle Hobbs, MD; Sara Stern-Nezer, MD

Due to their efficacy and favorable rates of complications when compared to vitamin K antagonist therapy, direct or novel oral anticoagulant...

Literature Watch

NEWS: Does Early Prophylactic Hypothermia Improve Outcomes After Severe TBI? Results of the Prophylactic Hypothermia to Lessen Traumatic Brain Injury-Randomized Clinical Trial (POLAR-RCT)

Written By: Sara Stern-Nezer, MD, MPH

Hypothermia mitigates multiple pathways implicated in secondary damage after neurological injury, but data on its potential role for treatment of...

Literature Watch

NEWS: Does Vitamin D Status Affect Outcomes in the Neurocritical Care Population?

Written By: Guan, J.; Karsy, M.; Brock, A.; Sara Stern-Nezer, MD, MPH

Read the article.* *You will need to log in to US National Library of Medicine National Institutes of Health to read this...

Literature Watch

NEWS: Variations in ICP After Decompressive Craniectomy Are Associated With Outcomes

Written By: Sara Stern-Nezer, MD, MPH

This study investigated the association between ICP and outcome after decompressive hemicraniectomy (DH) in patients with malignant cerebral...

Literature Watch

NEWS: No Benefit to IV Sodium Bicarbonate or Acetylcysteine for Prevention of Contrast-Associated Acute Kidney Injury in High-Risk Patients: The PRESERVE Trial

Written By: Sara Stern-Nezer, MD, MPH

This study was a multi-site, international double-blind, placebo and drug-controlled RCT done between 2013 and 2017. Patients with decreased...

More Literature Watch

Literature Watch

Optimal Head-of-Bed Positioning Before Thrombectomy in Large Vessel Occlusion Stroke

Written By: NCS Staff

For patients with large vessel occlusion (LVO) stroke, 0° head positioning helps to maintain clinical stability and prevent exacerbation as...

Literature Watch

Early Tirofiban Infusion after Intravenous Thrombolysis for Stroke

Written By: NCS Staff

Based on results from the ASSET-IT clinical trial, administration of tirofiban within 1 hour of I.V. thrombolysis correlates with better odds of...

Literature Watch

Intra-arterial Tenecteplase for Acute Stroke After Successful Endovascular Therapy

Written By: NCS Staff

Researchers conducted a prospective trial to learn more about the clinical value of intra-arterial tenecteplase for acute stroke survivors...