A study of more than 555,000 people with intracerebral hemorrhage (ICH) found an association between minimally invasive surgery (MIS) and lower in-hospital mortality and favorable discharge disposition. The retrospective cohort study included patients with a nontraumatic ICH enrolled in the American Heart Association Get With the Guidelines-Stroke Registry from 2011 through 2021. A total of 703 patients had MIS: 312 had stereotactic surgery and 391 had endoscopic surgery. In-hospital mortality – the primary outcome  - in the matched cohort occurredn13.5% of 446 patients who had MIS and 23.5% of 35,361 patients without surgery. Regression analyses found an association between MIS and lower in-hospital mortality (adjusted odds ratio, 0.50 [95% CI, 0.39–0.65]) and favorable discharge disposition (adjusted odds ratio, 1.93 [95% CI, 1.61–2.32]); however, there was no association with ambulatory status or functional outcomes. There was an independent association between stereotactic surgery and endoscopic surgery and lower mortality in other analyses. “These findings support efforts to understand the durable impact of MIS in patients with ICH,” the researchers conclude.