A post hoc analysis of the CLEAR study found that for patients with M2 segment middle cerebral artery occlusion, there was no difference disability outcomes or risk of symptomatic intracranial hemorrhage (sICH) when comparing endovascular thrombectomy (EVT) to medical management (MM) within the 6-24 hour time window. The study, conducted at 66 sites across 10 countries, included 496 patients with late-window stroke due to M2 occlusion, baseline National Institutes of Health Stroke Scale score of ≥5, and premorbid modified Rankin Scale (mRS) score of ≤2 who received EVT or MM alone. In analyses adjusted using inverse probability of treatment weighting, there was no significant advantage of EVT compared with MM in terms of improving functional outcomes at 90 days after stroke. EVT did not lead to a better shift in the mRS and did not increase the rate of functional independence (an mRS score of 0-2). Additionally, there were no statistically significant differences in sICH and 90-day mortality between the two treatment groups, the researchers report.